Due to impurity of ones hands when they awake from sleep, it is forbidden to walk four feet with that contamination...”
Zohar Hakadosh Daf Yud Amud Bet
One should wash their hands immediately when they rise, even if they are laying in bed. One should not walk four feet without performing Netilat Yadayim. It is important to be extremely wary of this
Mishna Brura, Siman Alef, Seif Katan Beit
...and so one should be stringent upon himself and prepare the articles needed to avoid walking four feet without washing first
Ben Ish Chai ,Shana Alef, Parshat Toldot, Halacha Vav